Characterization of Ibuprofen-Loaded MgO by One-Step Mid- and Far-FT-IR Spectroscopy

نویسندگان

چکیده

One-step mid- and far-Fourier-transform (FT)-IR spectroscopy is a facile powerful tool that provides various information regarding chemical crystal states. However, its potentially high applicability has not been sufficiently demonstrated. In the present study, ibuprofen (IB)-loaded MgO samples are prepared via different methods, they evaluated using scanning electron microscopy (SEM), thermogravimetry-differential thermal analysis (TG-DTA), X-ray diffraction (XRD), N2 adsorption-desorption measurement, CO2 temperature-programmed desorption technique (CO2-TPD), FT-IR spectroscopy. The obtained results indicate IB becomes ionized, amorphous, and/or dispersed by MgO. Since CO2-TPD result shows possesses basic surfaces, it considerable acid–base interactions cause above Furthermore, spectra in far-IR regions also suggest physical properties of IB-loaded changes through interactions. Therefore, characterization one-step far-FT-IR measurements can provide valuable

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ژورنال

عنوان ژورنال: Chemical & Pharmaceutical Bulletin

سال: 2021

ISSN: ['0009-2363', '1347-5223']

DOI: https://doi.org/10.1248/cpb.c20-00564